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WSIPP’s Board of Directors authorized WSIPP to work on a joint project with the MacArthur Foundation and the Pew Charitable Trusts to extend WSIPP’s benefit-cost analysis to certain health care topics. An important goal is to determine whether there are strategies that can help states control Medicaid and other health care costs. This report reviews evidence on five topics: “lifestyle” programs designed to prevent diabetes; behavioral interventions to reduce obesity; transitional care to prevent hospital readmissions; patient-centered medical homes to reduce health care costs; and programs to reduce avoidable emergency department visits.